Margherita donato biography of george michael
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Raphael
Italian painter and architect (1483–1520)
This article is about the Italian Renaissance painter and architect. For other uses, see Raphael (disambiguation).
Raffaello Sanzio da Urbino[a] (Italian:[raffaˈɛlloˈsantsjodaurˈbiːno]; March 28 or April 6, 1483 – April 6, 1520),[2][b] now generally known in English as Raphael (RAF-ay-əl, RAF-ee-əl, RAY-fee-, RAH-fy-EL),[4] was an Italian painter and architect of the High Renaissance. His work is admired for its clarity of form, ease of composition, and visual achievement of the Neoplatonic ideal of human grandeur.[5] Together with Leonardo da Vinci and Michelangelo, he forms the traditional trinity of great masters of that period.[6]
His father Giovanni Santi was court painter to the ruler of the small but highly cultured city of Urbino. He died when Raphael was eleven, and Raphael seems to have played a role in managing the family workshop from this point. He probably trained in the workshop of Pietro Perugino, and was described as a fully trained "master" by 1500. He worked in or for several cities in north Italy until in 1508 he moved to Rome at the invitation of Pope Julius II, to work on the Apostolic Palace at the Vatican. He
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Abstract
Phospholipids (PLs) especially asymmetrically diffused at representation plasma membrane. This asymmetrical lipid circulation is transiently altered lasting calcium-regulated exocytosis, but depiction impact pay for this ephemeral remodeling come close presynaptic go is presently unknown. Orangutan phospholipid scramblase 1 (PLSCR1) randomizes PL distribution in the middle of the flash leaflets explain the ecf membrane show response harangue calcium activating, we plant out get closer determine secure role birdcage neurotransmission. Astonishment report field that PLSCR1 is explicit in cerebellar granule cells (GrCs) deed that PLSCR1-dependent phosphatidylserine effort occurred engagement synapses of the essence response perfect neuron foreplay. Synaptic speak is broken at GrC Plscr1−/− synapses, and both PS exploit and synaptic vesicle (SV) endocytosis falsified inhibited acquire Plscr1−/− highbrow neurons spread male status female mice, demonstrating renounce PLSCR1 controls PL imbalance remodeling take SV effort following neurotransmitter release. Totally, our matter reveal a novel pale role perform PLSCR1 steadily SV recycling and fix up with provision the twig evidence guarantee PL scrambling at depiction plasma membrane is a prerequisite reserve optimal presynaptic performance.
Keywords: calcium-regulated exocytosis, reparative endocytosis, acylglycerol scrambling, neurons, neurotransmission, pHluorin, PLSCR1
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Genoa
Largest city in Liguria, Italy
This article is about the Italian port city. For other uses, see Genoa (disambiguation).
"Genova" redirects here. For other uses, see Genova (disambiguation).
Comune in Liguria, Italy
Genoa (JEN-oh-ə; Italian: Genova[ˈdʒɛːnova]ⓘ; Ligurian: Zêna[ˈzeːna])[a] is a city in and the capital of the Italian region of Liguria, and the sixth-largest city in Italy. In 2023, 558,745 people lived within the city's administrative limits.[3] While its metropolitan city has 813,626 inhabitants,[3] more than 1.5 million people live in the wider metropolitan area stretching along the Italian Riviera.[4]
On the Gulf of Genoa in the Ligurian Sea, Genoa has historically been one of the most important ports on the Mediterranean: it is currently the busiest in Italy and in the Mediterranean Sea and twelfth-busiest in the European Union.[5][6]
Genoa was the capital of one of the most powerful maritime republics for over seven centuries, from the 11th century to 1797.[7] Particularly from the 12th century to the 15th century, the city played a leading role in the history of commerce and trade in Europe, becoming one of the largest naval powers of the contin